Endocrine Abstracts

Aim: Metformin is usually well-tolerated and commonly used oral-antidiabetic in type-2 diabetes and pre-diabetes. The most common side effects are gastrointestinal (GI) ones. It is proposed that, extended-release form of metformin has less gastrointestinal side effects. We aimed to compare the extended-release and normal-release form metformin in type-2 diabetic and prediabetic patients for gastrointestinal tolerability, weight effect and glycemic control.<p class="abstext...

Introduction: SGLT2 inhibitors have been an important step in the treatment of diabetes. With numerous controlled experimental studies of these antidiabetic drugs, evaluation of real-life data after entry into clinical practice is an important condition. In our study, it was aimed to evaluate short-term results on glycemic control and weight loss in a narrow group of patients in the single tertiary medical center.Methods: The study was retrospectively de...

Introduction: Polycystic ovary syndrome (PCOS) is a common, multifaceted endocrinopathy associated with metabolic alterations such as insulin resistance, hyperinsulinemia, dyslipidemia, and obesity, and thereby an increased risk of developing type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). Endothelial dysfunction and chronic inflammation are early findings in the atherosclerotic process. Elevated serum levels of uric acid may reflect low-grade chronic inflamm...

Background: The polycystic ovary syndrome (PCOS) is often seen in reproductive age women. Although the ratio of insulin resistance is not knowm definitely in PCOS patients it is thought to be between 50 to 65%. Several studies have shown that low serum 25-Hydroxy Vitamin D (25(OH) D) levels are associated with high body mass index (BMI), insulin resistance, and waist/hip circumference, but it has not yet been clearly determined. In this study, we aimed to determine the correla...

Background: Antiphospholipid syndrome (APS) is characterized by venous or arterial thrombosis and/or an adverse pregnancy outcome in the presence of persistent laboratory evidence of antiphospholipid antibodies. Loss of adrenal function due to bilateral adrenal vein thrombosis, resulting in hemorrhagic infarction, may occur in association with APS.Case presentation: We present the case of a 45-year-old woman with APS diagnosis since she was 37, with hist...

Primary Hyperparathyroidism is a common endocrine disorder characterized with high parathyroid hormone (PTH) and calcium (Ca) levels. Although most of the patients are asymptomatic, some patients may be presented with renal, gastrointestinal, musculoskeletal, neurologic or cardiovascular signs associated with hypercalcemia or elevated parathyroid hormone related findings such as bone disease, nephrolithiasis, hypophosphatemia increased production of calcitriol, hypomagnesemia,...

Background: Brown tumor of bone is a non-neoplastic lesion resulting from abnormal bone metabolism in hyperparathyroidism. Brown tumor, as the only and initial symptom of normocalcemic primary hyperparathyroidism is extremely rare.Case presentation: A 69-year-old female patient was admitted to the hospital with a mass in the right thigh. A mass lesion of the right distal femur with bone and soft tissue infiltration was observed in the lower extremity mag...

Background: Obesity and diabetes are major causes of morbidity and mortality that are increasing all over the world. As obesity is a major risk factor for type 2 diabetic patients, weight loss has an important place in the treatment of type 2 diabetic patients. In our study, it’s aimed to evaluate the effects of exenatide and laparoscopic sleeve gastrectomy (LSG) in obese diabetic patients on the clinical and laboratory parameters.Subjects and metho...

Objectives: Obesity is a chronic and progressive disease that limits physical activity, causes psychological problems, and finally leads to social isolation of the person. Detecting the factors affecting obesity and its prevalence in the populaton are important steps in dealing with the problem. In this study, we aimed to evaluate the obesity prevalence and the factors affecting this prevalence in randomly selected volunteers from residents of the city of Bursa.<p class="a...

Background: Aggressive pituitary adenomas (APAs) take place phenotypically between benign pituitary adenomas and pituitary carcinomas with systemic metastasis. Frequent recurrence and resistance to conventional treatments are characteristic features of APAs in their clinical course. Temozolomide is an alkylating agent that has been used in the treatment of pituitary carcinomas and APAs since 2006. Herein, we report a patient who received temozolomide treatment due to APA.<...